Lamina Cribrosa Pore Diameter and Spaceflight-Associated Neuro-ocular Syndrome—Reply
نویسندگان
چکیده
منابع مشابه
Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk
PURPOSE To investigate how the lamina cribrosa (LC) microstructure changes with distance from the central retinal vessel trunk (CRVT), and to determine how this change differs in glaucoma. METHODS One hundred nineteen eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) of 105 subjects were imaged using swept-source optical coherence tomography (OCT). The CRVT was manually delineated at th...
متن کاملLamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
Purpose The purpose of this study was to determine how the architecture of the lamina cribrosa (LC) microstructure, including the shape and size of the lamina pores, influences the IOP-induced deformation of the neural tissues within the LC pores using computational modeling. Methods We built seven specimen-specific finite element models of LC microstructure with distinct nonlinear anisotropi...
متن کاملHuman lamina cribrosa insertion and age.
PURPOSE To test the hypothesis that in healthy human eyes the lamina cribrosa (LC) insertion into the pia mater increases with age. METHODS The optic nerve heads (ONHs) of donor eyes fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under bright- and dark-field conditions. A 3-dimensional (3D) model of each ONH was reconstructed. From the 3D models we measured the area ...
متن کاملAxon deviation in the human lamina cribrosa.
AIMS To examine the course taken by individual retinal ganglion cell axons through the human lamina cribrosa. METHODS Retinal ganglion cell axons were labelled using the retrograde tracer horseradish peroxidase applied directly to the optic nerve in two normal human eyes removed during the course of treatment for extraocular disease. RESULTS A majority of axons took a direct course through ...
متن کاملMorphometry of the human lamina cribrosa surface.
The lamina cribrosa is a sieve-like perforation in the posterior part of the sclera, that allows passage of the retinal ganglion cell axons and central retinal vessels and preserves a pressure gradient between the intraocular and extraocular space. It has been termed the primary site of glaucomatous damage to the optic nerve. Using electron microscopy, the authors morphometrically evaluated the...
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ژورنال
عنوان ژورنال: JAMA Ophthalmology
سال: 2019
ISSN: 2168-6165
DOI: 10.1001/jamaophthalmol.2019.3322